Below, in alphabetical order, is a list of Seguin’s clubs and organizations, along with their sponsors. Click on any club name to learn more about its background, planned activities, regular meeting schedule, contact information, and more.
| Academic Decathlon (David Crocker, Sohrab Irani) |
| Art (Lennie Roberson) |
| Band (Grady Niblo) |
| Chess Club (Donna Marshall-Knowles) |
| Choir (Stanley Moody, Mariah Spiry) |
| College Prep Club (Christy Cleger) |
| Computer Science Club (Jennifer Reese) |
| Drama Club / Theatre (Robert Krecklow) |
| Drum Line (Angel Briseno) |
| Environmental Club (Donna Marshall-Knowles, Richard Dickerson, James Dumond) |
| FCA (Fellowship Christian Athletes) (Chris Rose) |
| FCCLA (Family & Consumer Science) (Cathy Ownby, Katie Brunk) |
| Freshman Class |
| HOSA (Health Occupations Students of America) (Shannon Willis) |
| Junior Class (Mandi Crowder, Cheryl Speer) |
| Key Club (Bethany Long) |
| SVA (Latin Club) (Marshal Westfall-Haessig) |
| MSA (Muslim Student Association) (Lennie Roberson) |
| NAHS (National Arts Honor Society) (Lennie Roberson, Brandi Cox, Evan O’Neal) |
| NHS (National Honor Society) (Cheryl Speer, Amanda Crowder) |
| NTHS (National Technical Honor Society) (Katie Brunk, Anna Fotoohi, Cathy Ownby) |
| Newspaper (Jon Neilsen) |
| Orchestra (Melina Shaffer, Kristin Davis) |
| Prom Committee (Amy Croft, Kelly Limer, Teresa Menard) |
| PTSA (Parent, Teacher, Student Association) (Darwin Brown) |
| Seguin Girls Rock! / Seguin M.E.N. (Oluchi Igbokwe) |
| Seguin Nation (Stephen Hafford) |
| Seguin Spirit (Teresa Menard) |
| Senior Class (Amy Croft, Kelly Limer, Teresa Menard) |
| Spanish Club (Marlene Cristino) |
| SOAR (Amy Croft) |
| Starline (Shaq Mouton) |
| Sophomore Class |
| Student Council (Amy Croft) |
| TAFE (Teachers Association of Future Educators) (Cathy Ownby) |
| Theatre (Robert Krecklow) |
| UIL Academics (Brian Brenner) |
| Yearbook (Alberto Rodriguez) |