| Seguin Clubs and Organizations | Sponsor |
|---|---|
| African Student Association | Oluchi Igbokwe |
| Academic Decathlon | David Crocker / Richard Dickerson |
| ANIME Club | Matthew Vivian |
| Band/Color Guard | Phillip Cadenhead / Grady Niblo / Angel Briseno |
| BB Cougs Club | Sean Fanning |
| Calculus Club | Brittany Paradiso |
| Chess Club | Donna Marshall-Knowles |
| Computer Science Club/UIL | Jennifer Reese |
| Cougar Camp | William Gordon |
| E-Sports/Video Gaming | Evan O’Neal |
| FCA (Fellowship of Christian Athletes) | Johnathane Gaffney |
| Global Youth Service | Marshal Westfall-Haessig |
| HOSA (Health, Occupations, Science Association) | Anna Fotoohi |
| Key Club | Marshal Westfall-Haessig |
| Latin Club/SVA | Marshal Westfall-Haessig |
| MSA (Muslim Student Association) | Lennie Roberson |
| NAHS (National Art Honor Society) | Lennie Roberson / Evan O’Neal |
| NHS (National Honors Society) | Beth Simmonds |
| Newspaper | Jon Nielsen |
| Orchestra | Melina Shaffer / Kirsten Davis |
| Photojournalism | Jon Nielsen |
| Physics Club | Richard Dickerson |
| PTSA (Parent, Teacher, Student Association) | Rosa Darkwa / Marsona Jackson / Clarissa Rodriguez / Beth Simmonds |
| Seguin Art Club | Lennie Roberson |
| Seguin Criminal Justice | Michael Holguin |
| Seguin Engineering Team | Renwick Ridgeway |
| Seguin Environmental Club | Donna Marshall-Knowles |
| Seguin Girls Rock/Seguin Men | Oluchi Igbokwe / Johnathane Gaffney |
| Spanish Club | Marlene Cristino-Roberts |
| Starline | Shaq Mouton |
| STEM Sisters | Jennifer Reese |
| STUCO (Student Council) | Marc Alcorn |
| Theatre | Justin Lemieux / Gregory Wilson |
| UIL Academics | Jennifer Reese |
| UIL Accounting | Anthony Robinson |
| UIL Computer Applications | TBA |
| UIL Computer Science | Jennifer Reese |
| UIL Journalism | Jon Nielsen |
| Yearbook | Jon Nielsen |